A flicking system for producing 3D cells

    Project Code: 249
    2D cell model has been used widely and routinely used for stem cell, cancer cell and mammalian cell cultures. Current 2D (monolayer) cell culture in biological laboratory producing monolayer of cells for analysis and cell study is far from the physiological system which is in three dimensional with multicellular structure. The current flicker system allows the reconstruction of viable multilayer cellular structures that could be used for a model mimicking the tissue system. It can be used to bridge between 2D cell model and animal model to reduce the failure of drug testing by providing more realistic cell model. This innovation provides a comprehensive solution to the problems faced upon using the conventional method.
    By UTHM
Project Overview
  • This invention consists of a flicker system (end-product) which can produce 80 pieces/min of microencapsulated 3D cells such as keratinospheroids (microtissue of keratinocytes) in calcium alginate.Designing of the RC sensor was done using 3D printer with Acrylonitrile Butadiene Styrene (ABS) filament, rendering it to be accurate geometrically.
  • The existing product in the market are such as HydroMatrix™ Peptide Hydrogel, 3D Petri Dish®, GravityPLUS™, NanoShuttleTM-PL that are more of polymer based micromolds that enable cells to aggregate in microwells. The difficulty in controlling the consistency in depositing cells in each microwell through pipetting.
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