Hyaline articular cartilage protects the bones of diarthrodial joints from forces associated with load bearing, friction, and impact. Despite its remarkable mechanical durability, hyaline cartilage has very limited capacities for self-repair once injured. Often, Isolated cartilage lesions, if left untreated degenerates to osteoarthritis.
The focus in cartilage treatments has evolved from repair, replacement and most recently, regeneration. Regeneration treatments includes different generations of autologous cartilage implantations and the use of mesenchymal stem cells. In our recent invention, we have shown that chondrogenically induced bone marrow stem cells (BMSCs) are better than uninduced BMSCs and could be a treatment option for cartilage degenerations and osteoarthritis.